Optimized Human iPSC-Derived Sensory Neurons for Pain and Neuropathy Research
Nociceptive sensory neurons respond to diverse range of stimuli and are critical transducers of pain and neuropathic signals. As chronic pain remains a leading cause of disability worldwide and has a clear unmet therapeutic need, an understanding of sensory mechanisms is essential to meet the demand for novel analgesics.
Many promising drugs which show efficacy in animal models have failed in the clinic due to interspecies variance in nociception mechanisms. Hence, consistent, scalable human in vitro models are required to accelerate potential therapeutics to the clinic.
This poster highlights how human induced pluripotent stem cells (hiPSCs) can be precision reprogrammed into highly pure populations of sensory neurons to provide a more relevant model to understand analgesic efficacy.
Download this poster to discover:
- Consistent and defined human nociception models that are ready to use in seven days
- How precision reprogrammed sensory neurons show a functional nociceptive phenotype
- How the protocol to generate sensory neurons is simple, and accessible to scientists without iPSC expertise
