Generating Pure, Consistent GABAergic Neurons From hiPSCs

Abnormal GABAergic function is associated with a variety of neurological diseases. Hence, understanding neuronal activity is crucial for the discovery of novel treatments and therapeutic drugs. 

While animal models and primary cells remain valuable resources, neuronal drug development faces many challenges. Not least, the variability and inaccuracy of traditional model systems can result in the failure to translate data into successful clinical trials.

This poster highlights how human induced pluripotent stem cells (hiPSCs) can be precision reprogrammed to generate a highly pure population of GABAergic neurons for a more accurate model of neuronal circuits. 

Download this poster to learn more about:

• Consistent, accurate and functional iPSC-derived inhibitory neuron models
• Human iPSC-derived GABAergic neurons that show spontaneous functional activity, including calcium signalling
• Optimized protocols for inhibitory/excitatory neuron co-culture that accurately model cortical networks