Combining Imaging and OMICs: MALDI Guided SpatialOMx® Probes Proteomic Mass Profiles of Breast Cancer Tumor Subpopulations

While MALDI Imaging provides a direct link between tissue pathology and molecular expression, it lacks the in-depth molecular characterization attributed to 4D-OMICS strategies.  SpatialOMx, an integration of MALDI Imaging with 4D-OMICs, yields a more comprehensive understanding of biochemical activity within the tissue microenvironment.

Download this poster to discover how the SpatialOMx workflow using timsTOF fleX provides detailed in-situ characterization of bioactivity across different tumor cell subpopulations by:

• Automated segmentation of tissue microenvironment based on label-free mapping of molecular expression
• Identification and location of distinctive tissue subtypes for laser microdissection and targeted OMICS analysis
• Performing in-depth 4D-proteomics analysis of excised material using PASEF