Cell Signaling

Aberrant Wnt signaling has also been identified as a key mechanism in cancer biology. This article summarizes both the canonical (β-catenin dependent) and non-canonical (β-catenin independent) signaling pathways. It also highlights the role of Wnt signaling in numerous cancers and discusses novel approaches to targeting the pathway.

Here, Caroline Hill, Ph.D., from The Francis Crick Institute, UK, shares insight into cell communication and signaling dysregulation – her area of expertise. Her research group are focused on understanding the signals sent to, and sent by cells – and how this communication influences cellular behavior. As well as touching on her research, Caroline discusses the evolution of cancer and suggests strategies for encouraging more women to pursue a career in STEM.

We typically think of a cancerous tumor as a bunch of abnormal cells gone rogue, but the situation is more complicated. This article will explore cell-to-cell communication’s role in cancer development, its influence on metastasis and how research is expanding our knowledge of the disease.

This article discusses the relationship between cell signaling and cancer, highlights key signaling pathways involved in cancer, and explores how critical mediators of aberrant signaling can be turned into therapeutic targets for cancer.