Latest App Notes & Case Studies
App Note / Case Study
CAR T: A Promising Cell Therapy for Cancer Treatment
CAR-T cell therapy has emerged as one of the most promising novel treatments in the fight against cancer.
App Note / Case Study
Integrating Laboratory Equipment Into Computerized Systems
Laboratory Information Management Systems (LIMS) is becoming increasingly important in GMP regulated environments in order to ensure data integrity and faster working practices.
App Note / Case Study
Transitioning From RUO to cGMP for Clinical Trials
Both RUO and cGMP compliance play important roles in the drug discovery pipeline. However, meeting regulatory demands can be a challenge when accelerating new drugs to the clinic.
App Note / Case Study
Discover an Automated Workflow for Precise Metabolite Identification
Discover an automated processing workflow that utilizes both EAD and CID data for the most confident characterization of pharmaceutical drug metabolites.
App Note / Case Study
Metabolic Preconditioning for Improved CAR-T Cell Therapy
Metabolism is a key driver of CAR-T cell fitness and function. Hence, metabolic preconditioning methods can enhance the bioenergetic capacity of CAR-T cells in culture, supporting their persistence and antitumor activity
App Note / Case Study
Highly Sensitive Mass Spectrometry Methods for Quantifying PROTACs
Protein-targeting chimeras (PROTACs) have gained significant attention recently due to their high potency in nanomolar drug concentrations and target selectivity. However, low test concentrations in complex matrices present analytical challenges.
App Note / Case Study
Identifying Metabolites With Confidence
Understanding the effects of in vitro drug metabolism is a key aspect of drug discovery and development. However, researchers must be able to make confident decisions quickly and easily.
App Note / Case Study
Using Electron Activated Dissociation (EAD) To Characterize Challenging Metabolites
Glucuronidation is an essential metabolic pathway for drug clearance and its characterization is crucial for optimizing the efficiency and safety of drug candidates.
App Note / Case Study
Complete Characterization of T-Cell Metabolism With a Single Assay
Metabolism has emerged as a key driver of T-cell antitumor function. This means that modulating metabolic programs of T cells can be used as a strategy to improve the antitumor efficacy of adoptive T-cell therapies.
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