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Latest App Notes & Case Studies

CAR T: A Promising Cell Therapy for Cancer Treatment content piece image
App Note / Case Study

CAR T: A Promising Cell Therapy for Cancer Treatment

CAR-T cell therapy has emerged as one of the most promising novel treatments in the fight against cancer.
Integrating Laboratory Equipment Into Computerized Systems content piece image
App Note / Case Study

Integrating Laboratory Equipment Into Computerized Systems

Laboratory Information Management Systems (LIMS) is becoming increasingly important in GMP regulated environments in order to ensure data integrity and faster working practices.
Understanding the Hidden Value of Quality content piece image
App Note / Case Study

Understanding the Hidden Value of Quality

Outsourcing quality management activities can save biomanufacturers time, money and resources. It can support scientists in bringing life-changing therapeutics to market swiftly and efficiently.
 Transitioning From RUO to cGMP for Clinical Trials content piece image
App Note / Case Study

Transitioning From RUO to cGMP for Clinical Trials

Both RUO and cGMP compliance play important roles in the drug discovery pipeline. However, meeting regulatory demands can be a challenge when accelerating new drugs to the clinic.
Discover an Automated Workflow for Precise Metabolite Identification content piece image
App Note / Case Study

Discover an Automated Workflow for Precise Metabolite Identification

Discover an automated processing workflow that utilizes both EAD and CID data for the most confident characterization of pharmaceutical drug metabolites.
Metabolic Preconditioning For Improved CAR-T Cell Therapy content piece image
App Note / Case Study

Metabolic Preconditioning for Improved CAR-T Cell Therapy

Metabolism is a key driver of CAR-T cell fitness and function. Hence, metabolic preconditioning methods can enhance the bioenergetic capacity of CAR-T cells in culture, supporting their persistence and antitumor activity
Highly Sensitive Mass Spectrometry Methods for Quantifying PROTACs content piece image
App Note / Case Study

Highly Sensitive Mass Spectrometry Methods for Quantifying PROTACs

Protein-targeting chimeras (PROTACs) have gained significant attention recently due to their high potency in nanomolar drug concentrations and target selectivity. However, low test concentrations in complex matrices present analytical challenges.
Identifying Metabolites With Confidence content piece image
App Note / Case Study

Identifying Metabolites With Confidence

Understanding the effects of in vitro drug metabolism is a key aspect of drug discovery and development. However, researchers must be able to make confident decisions quickly and easily.
Using Electron Activated Dissociation (EAD) To Characterize Challenging Metabolites content piece image
App Note / Case Study

Using Electron Activated Dissociation (EAD) To Characterize Challenging Metabolites

Glucuronidation is an essential metabolic pathway for drug clearance and its characterization is crucial for optimizing the efficiency and safety of drug candidates.
Complete Characterization of T-Cell Metabolism With a Single Assay content piece image
App Note / Case Study

Complete Characterization of T-Cell Metabolism With a Single Assay

Metabolism has emerged as a key driver of T-cell antitumor function. This means that modulating metabolic programs of T cells can be used as a strategy to improve the antitumor efficacy of adoptive T-cell therapies.
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