Latest App Notes & Case Studies

Monoclonal antibody (mAb)–based therapeutics have been very successful in treating various diseases, including cancer. The manufacturing of these therapeutic antibodies is a complex operation with low levels of aggregates being a critical quality attribute of the final product, as this will impact the biological activity.

When planning for your sample storage needs, there’s no doubt you’ve discovered the many types of freezers on the market—upright, under-counter, side-by-side, and chest, to name a few. So, what advantages do chest freezers have over other types of freezers?

In the field of protein therapeutics, a protein-polymer conjugation strategy can improve the protein’s clinical potential by overcoming some of the challenges, such as physiochemical instability, immunogenicity and suboptimal circulation half-life.

Bile acids are well known for their roles in cholesterol homeostasis, lipid absorption and as metabolic signaling molecules. They are implicated in a variety of disease states and therefore serve as an exciting focus on research in novel biomarker discovery.

Identifying novel biomarkers with bottom-up proteomics remains a substantial challenge due to the wide concentration ranges and potentially low abundance of important analytes.

Need a routine analytical technique that can provide protein expression profiling and targeted drug imaging? MALDI Imaging is used to determine the spatial distribution of molecules in a tissue section, for more complete multiomic information.

Adeno-associated virus (AAV) technology has become a crucial method for delivering gene therapy drugs and vaccines. The quantitation of viral capsids enables researchers to ensure that AAV preparations are of high quality and potency. However, challenges remain with the accurate quantitation and detection of multiple AAV serotypes.

Lipid nanoparticles (LNPs) have emerged as effective delivery vehicles for mRNA vaccines and nucleic acid-based drugs. Hence, the analysis of their composition, stability, and biological interactions is essential in drug development and delivery.

Accelerated solvent extraction (ASE) is an effective extractable profiling technique. However, the poor solubility of certain compounds can result in result in reduced recovery rates and can compromise analytical accuracy.

Stringent safety requirements associated with the analyses of carcinogenic and mutagenic impurities can present significant challenges. Methods must achieve a high level of sensitivity and selectivity while maintaining sufficient sample throughput.