Latest App Notes & Case Studies

This application note demonstrates how reliable kinetics and affinity can be obtained from single measurement data, increasing sample throughput and saving sample material.

Adeno-associated virus (AAV) technology has become a crucial method for delivering gene therapy drugs and vaccines. The quantitation of viral capsids enables researchers to ensure that AAV preparations are of high quality and potency. However, challenges remain with the accurate quantitation and detection of multiple AAV serotypes.

Lipid nanoparticles (LNPs) have emerged as effective delivery vehicles for mRNA vaccines and nucleic acid-based drugs. Hence, the analysis of their composition, stability, and biological interactions is essential in drug development and delivery.

Accelerated solvent extraction (ASE) is an effective extractable profiling technique. However, the poor solubility of certain compounds can result in result in reduced recovery rates and can compromise analytical accuracy.

Stringent safety requirements associated with the analyses of carcinogenic and mutagenic impurities can present significant challenges. Methods must achieve a high level of sensitivity and selectivity while maintaining sufficient sample throughput.

A major challenge preventing transformative gene therapies from reaching patients is the lack of fit-for purpose potency assays, which are some of the most important assays in an analytical package but are often the most complex and high-risk.

This compendium serves as a user-friendly reference for assay design on both bio-layer interferometry (BLI) and surface plasmon resonance (SPR) systems.

Custom oligo synthesis can result in the formation of impurities. Hence, final products must be characterized to ensure they meet quality assurance and control standards.

LC/MS methods can be used to analyze a wide range of oligo samples. However, ion-pairing reagents can interfere with analyses and present challenges in multi-use systems.

This application note demonstrates how Single Cell Immune Profiling and Barcode Enabled Antigen Mapping (BEAM) can be used to profile thousands of hPBMCs from a single donor.