Latest Whitepapers

Liquid chromatography mass spectrometry (LC-MS) plays a pivotal role in the precise analysis of trace molecules. To enhance sensitivity and accuracy, it is crucial for researchers to upgrade from HPLC-grade solvents to LC-MS grade solvents that are specially designed to meet the stringent requirements of modern LC-MS systems.

Adeno-associated viral vector (AAV) has become a preferred gene therapy delivery modality; however, AAV manufacturing is not without its challenges, whether that is using crude samples, a lack of standardized methods or incompatible techniques.

Despite the success of AAV for gene therapies and vaccines, many challenges still exist within AAV manufacturing. To ensure the safety and efficacy of a therapeutic, it is crucial to accurately determine the percentage of capsids that carry the gene of interest.

A scalable and robust solution for all stages of the gene therapy workflow to meet regulatory standards is essential, however, as the field is more recent, liquid media is the common format even though it can be more expensive and have a shorter shelf life.

Whether scaling up production in-house or using a contractor there are many factors to consider. This whitepaper outlines how outsourcing process development to an experienced provider can improve workflow efficiency and reduce overall costs.

This whitepaper highlights the key molecular components of ADCs and the challenges and opportunities for their future development.

Tissue dissociation is a crucial sample preparation step that enables the isolation of specific cell populations for downstream applications such as single-cell RNA sequencing. Enzymatic tissue dissociation is widely used, but some researchers have concerns about the impact of enzymes on cell marker expression.

mRNA-based therapies, from infectious disease vaccines to genetic disorder treatments, are gaining traction. However, mRNA purification methods must evolve beyond traditional precipitation techniques to meet the demands of large-scale therapeutic production.

As researchers endeavor to map the architecture of the brain, many rely on tissue dissociation approaches to prepare single-cell suspensions for downstream analysis. Howev er, such conventional methods can involve enzymes and heat, which are known to induce transcriptional and proteotype changes in brain cells.

This whitepaper explores the latest reagents and software available to enhance tumor exome profiling for the generation of accurate, actionable clinical insights.