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Latest App Notes & Case Studies

Novel Aggregation-Specific Fluorogen Monitors Prefibrillar Protein Aggregation by Fluorescence Polarization content piece image
App Note / Case Study

Novel Aggregation-Specific Fluorogen Monitors Prefibrillar Protein Aggregation by Fluorescence Polarization

Highly ordered protein aggregates, termed amyloid fibrils, are associated with a broad range of diseases, many of which are neurodegenerative for example Alzheimer’s and Parkinson’s. The transition from soluble, functional protein to insoluble amyloid fibril occurs via a complex process involving the initial generation of highly dynamic early stage aggregates or prefibrillar species.
Achieve Highly Sensitive Viral Detection with the SARS-CoV-2 NGS Assay - RUO content piece image
App Note / Case Study

Achieve Highly Sensitive Viral Detection with the SARS-CoV-2 NGS Assay - RUO

Download this application focus to learn more about the solutions available to optimize the sensitivity of viral detection.
Genomic DNA Extractions Compared With the Agilent Femto Pulse System content piece image
App Note / Case Study

Genomic DNA Extractions Compared With the Agilent Femto Pulse System

Large-insert libraries require specific quality conditions of the starting genomic DNA (gDNA) material for successful outcomes. Physical, enzymatic and chemical shearing of gDNA into smaller fragments can occur at many different points during extraction and handling of gDNA.
Quantifying T Cell Response in 3D Tumor Spheroids Using Advanced Flow Cytometry Workflows content piece image
App Note / Case Study

Quantifying T Cell Response in 3D Tumor Spheroids Using Advanced Flow Cytometry Workflows

Discovery of novel immunotherapies that specifically target and enhance the T cell response against cancer is a rapidly expanding research area. Robust and relevant in vitro models for evaluation of these immunotherapies is essential throughout their development.
Improved GPCR Engineering With Synthetic Site Saturation Variant Libraries content piece image
App Note / Case Study

Improved GPCR Engineering With Synthetic Site Saturation Variant Libraries

Download this app note to learn more about how saturation mutagenesis can be used to identify functional GPCR variants, why error-prone PCR results in low variant representation as well as the advantages of synthetic saturation mutagenesis libraries.
Recent Developments in Covid Virology content piece image
App Note / Case Study

Recent Developments in Covid Virology

COVID-19 is caused by the SARS-CoV-2 virus. While some patients have mild or asymptomatic illness, for others it can be fatal. Understanding the immune response to SARS-CoV-2 at a molecular level is useful for the development of effective vaccines, treatments and prognostic tests.
Accurately Analyze Fluorescent Widefield Images content piece image
App Note / Case Study

Accurately Analyze Fluorescent Widefield Images

The specificity of fluorescence microscopy allows researchers to accurately observe and analyze biological processes and structures quickly and easily, even when using thick or large samples. However, out-of-focus fluorescence increases background, reduces contrast and makes accurate image segmentation more challenging.
Pushing the Boundaries of High Sensitivity Epigenetic Applications content piece image
App Note / Case Study

Pushing the Boundaries of High Sensitivity Epigenetic Applications

Download this free application focus to learn more about innovative next-generation methylation detection systems.
Microbubbles Offer a Versatile, Flexible Platform for Targeted Capture of Diverse Analytes content piece image
App Note / Case Study

Microbubbles Offer a Versatile, Flexible Platform for Targeted Capture of Diverse Analytes

Download this app note to discover a solution that can be used with any biotinylated affinity molecule, enables floatation-based separation of diverse targets as well as provides workflows that are exceptionally gentle on delicate analytes.
The Development of a Sensitive and Reliable qRT-PCR-Based SARS-CoV-2 Wastewater Analysis Protocol content piece image
App Note / Case Study

The Development of a Sensitive and Reliable qRT-PCR-Based SARS-CoV-2 Wastewater Analysis Protocol

Wastewater testing offers valuable insight on community-level data for various analytes, including pathogens that are associated with infectious diseases. Quantitative reverse transcriptase PCR (qRT-PCR) is well suited for wastewater analyses of pathogens due to its sensitivity, scalability and cost-effectiveness.
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