Latest App Notes & Case Studies

Single cell and spatial technologies that profile gene expression across whole tissues are revolutionizing the resolution of molecular states in clinical tissue samples.

Data silos, lack of interoperability and the preservation of patient privacy all present challenges to the global sharing of genomic data.

Many downstream experiments in molecular biology, such as next-generation sequencing, depend on the use of reasonably pure nucleic acid samples in adequate concentration ranges.

One approach to develop drugs for infectious diseases involves a comprehensive understanding of human-pathogen protein interactions, as targeting host proteins helps reduce the possibility of drug resistance by creating a more significant evolutionary barrier for the virus.

Using genome-wide CRISPR knockout screens, followed by focused CRISPR screens, researchers at Boehringer Ingelheim probed the gene-phenotype relationship of human monocyte phagocytosis when the cells were challenged with Staphylococcus aureus.

Download this article to learn about a next-generation sequencing technology that integrates genetic and biochemical testing as well as can efficiently diagnose more than 180 metabolic diseases.

Because of this, plasmids ideally suit experimental protocols that include cloning. Inserting a piece of DNA into the linearized plasmid and generating multiple copies of the plasmid allows scientists to study DNA sequences or genes.

Comprehensive disease modeling can be challenging for many labs due to variations in reagents, cell culture conditions, technical inconsistencies across protocols and experiments and bandwidth limitations.

Single cell analysis in a spatially resolved context is the gateway to deciphering scientific questions in various application areas. Such analysis requires the highest available spatial precision combined with highly sensitive detection.

Consistent amplification uniformity during PCR is vital to making robust conclusions when comparing data obtained from wells at two different locations. But how can the effects of PCR plate consumables on amplification uniformity be mitigated?