Latest App Notes & Case Studies
App Note / Case Study
The Importance of Reproducibility for Gene Therapy Development
The scale of research into potential gene therapies often means that work is distributed across multiple locations. Investigators must have confidence that the results obtained at one site are consistent with results obtained at other sites participating in the study.
App Note / Case Study
Rapid Phosphoproteomics With DIA-PASEF
Data-independent acquisition (DIA) has been shown to increase the quantitative reproducibility and accuracy of MS-based phosphoproteomics. This app note explores the impact of dia-PASEF on the speed and sensitivity of phosphoproteomics.
App Note / Case Study
An Integrated Multiomic Approach for the Diagnosis of Metabolic Diseases
Inherited metabolic disorders (IMDs) are a vast and complex group of rare genetic diseases presenting throughout a patient’s life span.
App Note / Case Study
A Fully Integrated Spatial Biology Analysis Solution
Extracting biological insights from spatial data is vital to advancing science, however, the analysis of spatial multiomics data is only possible with a robust and scalable informatics solution.
App Note / Case Study
Distinguishing Oxidative Impurities From Ionizable Lipids Used in LNP Formulations
Lipid nanoparticles (LNPs), comprised of ionizable lipids, are used to deliver oligonucleotides to work as therapeutics or to stimulate the immune system, as in the initial mRNA-based COVID vaccines.
App Note / Case Study
Characterization and Relative Quantification of mRNA 5’-Capping
Products based on mRNA have broad potential for use as therapeutics, and because mRNA leverages the translational machinery of the host cells, there is a significantly reduced risk of unwanted post-translational modifications.
App Note / Case Study
Consistency is Key to Further Drug Discovery Research
Energy metabolism plays a central role in a wide variety of cellular and physiological processes. Therefore, a deep understanding of how disruption to energy metabolism impacts cells can help in therapeutic drug discovery and development.
App Note / Case Study
Going Library-Free for Protein Identification
Download this app note to discover a SWATH DIA workflow that:
Has the speed and sensitivity to acquire high-quality, high-resolution MS/MS data
Reduces the need to generate experimental libraries
Was used to identify 2-fold more proteins than a DDA workflow
Has the speed and sensitivity to acquire high-quality, high-resolution MS/MS data
Reduces the need to generate experimental libraries
Was used to identify 2-fold more proteins than a DDA workflow
App Note / Case Study
Ensuring Quality Control of IVT RNA Workflows
This tech note highlights technology that switches easily between DNA and RNA analysis to ensure quick and reliable quality checks and precise sizing of DNA and IVT RNA products.
App Note / Case Study
High Resolution Mapping of the Breast Cancer Tumor Microenvironment
Single cell and spatial technologies that profile gene expression across whole tissues are revolutionizing the resolution of molecular states in clinical tissue samples.
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