Latest App Notes & Case Studies

This application note outlines the importance of reagent consistency in organoid tissue culture.

Many targets implicated in diseases are refractory to knockdown by traditional therapeutics like antibodies and small molecules. They represent an exciting new modality, repurposing small molecule chemical tools to achieve selective degradation

The ability to study transcript isoforms in detail could have a significant impact on our understanding of health and disease. However, most commonly, bulk sequencing is the selected method that only provides an average of the transcripts expressed across your sample of cells.

Protein-targeting chimeras (PROTACs) have gained significant attention recently due to their high potency in nanomolar drug concentrations and target selectivity. However, low test concentrations in complex matrices present analytical challenges.

Download this app note to learn how you can select 20 individual CTCs in 10 minutes, this approach can be used for DNA, RNA or proteome analysis as well as how these target cells are selected and isolated in high purity from heterogenous backgrounds.

Serological pipettes are commonly used in cell culture applications when pipetting volumes greater than 1,000 µL. However, their plastic (disposable) nature, coupled with the inability to pre-set the volume and propensity to cause shoulder strain, are just some of the limitations faced by researchers in the lab.

Single-cell RNA sequencing produces a substantial amount of complex data that can be a burden if you don’t have time to become an expert in bioinformatics.

Spatial biology requires highly validated reagents to accurately resolve proteins in the tissue microenvironment. Although immunofluorescence techniques are some of the most commonly used research tools, there are no universally accepted guidelines for antibody validation.

Traditional methods are often low throughput, time-consuming and lack linearity. However, advanced flow cytometry has emerged as a more efficient alternative for biologics development.

CRISPR/Cas9 gene editing can result in off-target cleavage events, impacting the validity of your final results. Cleavage of unintended targets can cause impaired cell function, cell death or misleading conclusions. CIRCLE-seq is a sensitive in vitro assay that was developed to overcome the challenges associated with off-target screening.