Latest App Notes & Case Studies

During pharmaceutical development and manufacturing, there is always the question: are you following methods for current good laboratory practice or current good manufacturing practice?

Targeted next-generation sequencing (NGS) is a well-established and powerful tool for somatic oncology research. NGS pipelines for the analysis of somatic variants require efficient methods for enriched library preparation from challenging sample types, relevant, optimized enrichment panels and advanced bioinformatic tools.

Despite daily use in every life science laboratory, best pipetting practices are not as well-known as one might expect. Many users are self-taught and have never received formal pipetting training during their professional career.

Download this app note to discover a solution that boosts the numbers of proteins, peptides and PSMs in complex datasets as well as increases protein sequence coverage substantially.

While identifying single nucleotide variants (SNVs) and small insertions/deletions (indels) from NGS data has become routine and well established, it is still quite a challenge to accurately detect germline copy-number variations (CNVs) from exome sequencing data as compared to the more conventional methodologies for CNV detection, including comparative genome hybridization arrays.

The Shell Technology Center in Bangalore, India (STCB) is one of the three Technology Centers within Shell that supports both R&D and laboratories at Shell, including non-operating joint venture assets. The analytical laboratory at STCB observed that they were spending a lot of time and energy coordinating services with multiple vendors, each supplying and maintaining highly varied and separate systems.

The specificity of fluorescence microscopy allows researchers to accurately observe and analyze biological processes and structures quickly and easily, even when using thick or large samples. However, out-of-focus fluorescence increases background, reduces contrast and makes accurate image segmentation more challenging.

Setting up a qPCR is a tedious process consisting of multiple pipetting steps. One particularly challenging task is reformatting from microcentrifuge tubes into a 384 well plate, it is time consuming and requires a lot of concentration.

Download this app note to discover a surveillance assay that rill remain effective as new variants emerge whilst offering high sensitivity and capture efficiency.

Traditional methods require highly skilled technicians to run laborious, manual and time-consuming tests on multiple parameters and business growth can mean that these methods become unsustainable; causing a bottleneck that can slow production.