Latest How To Guides

Long-read sequencing enables the accurate identification and characterization of complex genomic features. It outperforms its short-read alternatives in de novo assembly, mapping, and variant calling applications.

Conventional bioassays often require labeled detection reagents to provide a measurable readout. However, modifications to molecular structure and/or function can skew results, and non-specific binding of the labels themselves can lead to an unwanted background signal.

Download this guide to learn more about what RNA-Seq is and the information it provides, advantages of RNA-Seq, the types of RNA-Seq available and what to consider when designing your experiment.

Since the discovery of elevated levels of nitrosamines in certain pharmaceuticals, reported in July 2018, finding the right solutions have become a major focus for many pharmaceutical manufacturers, particularly as they are considered probable human carcinogens.

This guide explores the critical role of ubiquitin in two protein degradation systems, the ubiquitin-proteasome system (UPS) and the autophagy–lysosomal system (ALS), in proteostasis.

The journey to discovering novel drug targets starts with building a deep understanding of the underlying biology. To achieve this, researchers are increasingly looking to 3D cell cultures to bridge the gap between 2D cell cultures and in vivo animal models.

This guide highlights the four major stages of targeted protein degradation, the challenges at each step, and the questions you should ask yourself to ensure your final product will result in a complete protein degradation.

Mitochondrial toxicity assessments are crucial to ensuring the safety and efficacy of candidate compounds during drug development.

Download this guide to discover tips on sample preparation, fluorescence, fluorochromes and your antigens, your cytometer and data analysis.

Download this guide to learn more about laboratory automation and the novel informatics solutions available to ensure sound and long-lasting investments.